N6-METHYLADENOSINE MODIFICATION OF HIV-1 RNA SUPPRESSES TYPE-I INTERFERON INDUCTION IN DIFFERENTIATED MONOCYTIC CELLS AND PRIMARY MACROPHAGES.

N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.

N6-methyladenosine (m6A) is a prevalent RNA modification that plays a key role in regulating eukaryotic cellular mRNA functions.RNA m6A modification is regulated by two groups of cellular proteins, writers and erasers that add or remove m6A, respectively.HIV-1 RNA contains m6A modifications that modulate viral infection and gene expression in CD4+

read more


The Humanities as Contradiction: Against the New Enclosures

This essay begins by surveying our current moment in the humanities, diagnosing the language of crisis that frames much of the discourse about them.It argues that the crisis is a manufactured economic one not a symbolic one.The problems with many recent proposals—such as the new aestheticism, surface reading, and postcritique—is that th

read more